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Drug Repurposing Screening Identifies Spironolactone as Potentially Effective Drug to Treat Symptoms of Schizophrenia

Schizophrenia is a complex human disease, caused both by individual genetic variation and lifestyle. Genome-wide association studies have implicated many molecular targets and biological pathways with this disease. One these pathways associated with schizophrenia is the so-called Neuregulin1 (Nrg1)-ERBB4 signaling pathway.