Validierungsförderung VIP+ Grant
BMBF awarded the Validierungs-förderung VIP+ Grant to the laboratory of the Founder Prof. Moritz Rossner for the development of EXTassay – an EXT-based technology platform for highly-parallel drug analysis
We want to identify first-in-class drugs for genetically complex neurological disorders for which no treatment is available.
We will accomplish this by correlating drug profiles generated with barcoding in disease-specific iPSC models to clinical features.
Our drug discovery engine in patient-derived disease models integrates underlying molecular root causes responsible for neurological disorders.
The technological progress made in biomedical research has radically changed the view to new treatment strategies.
Modern genetic technologies can deliver disease-relevant targets but are insufficient to refill the empty drug discovery pipeline. Innovative and systems level pharmacological strategies are needed to substantially improve both early and late stages of the drug discovery process.
Aging societies are confronted with dramatically increasing costs of the health care systems. The genetic causes of many severe diseases, which do not only affect the elderly, have been identified, but effective treatment options are rarely available.
We are providing cost-effective and highly innovative solutions to address critical and unmet needs of the pharmaceutical industry. We will help to improve the cost-benefit ratio in the process of the development of better medicines.
BMBF awarded the Validierungs-förderung VIP+ Grant to the laboratory of the Founder Prof. Moritz Rossner for the development of EXTassay – an EXT-based technology platform for highly-parallel drug analysis
Funding for promoting concepts and products/services to establish Systasy Bioscience GmbH.
Founded in Munich in July 2012 as spin OFF from the Max Planck Institute of Experimental Medicine, Göttingen.
Establishment and transfer of an ERBB4 acitvity assay to screen a large compound library for ERBB4 modulators.
First products and services sold
Development of a GPCR profiling tool.
The tool monitors GPCR activities by combining splitSENSOR assays and molecular barcodes as readouts
Partners in European Marie Curie ITN Network – PDZnet Development of genetic screening tools assessing PDZ protein function in neuronal signalling pathways and PDZ protein interactions to explore therapeutic potential.
Licensing of Systasy’s splitSENSOR patent to Boehringer Ingelheim Systasy Bioscience announces non-exclusive licence agreement with Boehringer Ingelheim forsplitSENSOR assays.
Zim Grant
Establishment of a GPCR screening tool for inverse agonists and testing of a compound toolbox. Collaboration with University of Jena, Institute for Organic Chemstry and Macromolecular Chemistry, providing novel compounds.
First coumpound screen that used the splitSENSOR technology published
SplitSENSOR-based screening of repurposed drugs identified spironolactone as antagonist of ERBB4, a schizophrenia risk gene. In a mouse model of schizophrenia, spironolactone improved relevant endophenotypes in these mice, sparking the initiation of clinical study to assess effectiveness of spironolactone in schizophrenic patients.
Profiling in iPSCs
Establishment of a profiling tool for induced pluripotent stem cells (IPSCs) and cell types differentiated thereof
Establishment of a multiparametric safety profiling assay to assess target selectivity and physiological pathway effects of neuroleptics in living cells