Barcoded profiling of G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) activities, resolving multi-specific drug actions.
The targetPROFILER is a profiling assay to monitor the activities of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) under diverse stimuli conditions. Activities and target specificities of various GPCRs can be simultaneously analysed using the EXTassay technology. The activity of a given GPCR is measured using the splitSENSOR technology and the individual signaling events can be simultaneously analysed using the EXTassay technology.
A wide range of GPCRs are covered in this assay:
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