Drug Repurposing Screening Identifies Spironolactone as Potentially Effective Drug to Treat Symptoms of Schizophrenia

Schizophrenia is a complex human disease, caused both by individual genetic variation and lifestyle. Genome-wide association studies have implicated many molecular targets and biological pathways with this disease. One these pathways associated with schizophrenia is the so-called Neuregulin1 (Nrg1)-ERBB4 signaling pathway.